_” LACTAMS Part.2 “_
This
issue of Enamine Product Focus highlights Lactams,
cyclic amide building blocks. There are numerous examples of Lactams usage
in drug discovery, e.g., β-lactam based antibiotics, oral anticoagulant
Rivaroxaban, and anticonvulsant Levetiracetam.
Rivaroxaban, 2008 :
-> Levetiracetam, 2000
The specific features of Lactam
building blocks that are of advantage to drug design are summarized in
the chart below.
Enamine’s
Lactam building block collection is represented by many useful
scaffolds, for example, piperidones, piperazinones, (thio)morpholiones,
pyrrolidones, and their benzo-fused analogues. From combinatorial chemistry
standpoint especially interesting lactams in our collection are those bearing
additional functionalities, such as carboxyl, chlorosulfonyl, and amino-groups.
>> Read More : http://www.enamine.net/index.php?option=com_content&task=view&id=147
Pauline
BalasHapusplease explain about lactam building block
in your blog, you write abaout Lactams can polymerize to polyamides.
BalasHapusi stiil confuse,,please, explain the mecanisme of Lactams can polymerize to polyamides !