Minggu, 10 Juni 2012

_” LACTAMS Part.2 “_
                                                  
This issue of Enamine Product Focus highlights Lactams, cyclic amide building blocks. There are numerous examples of Lactams usage in drug discovery, e.g., β-lactam based antibiotics, oral anticoagulant Rivaroxaban, and anticonvulsant Levetiracetam.


Rivaroxaban, 2008 :







 -> Levetiracetam, 2000



The specific features of Lactam building blocks that are of advantage to drug design are summarized in the chart below.














Enamine’s Lactam building block collection is represented by many useful scaffolds, for example, piperidones, piperazinones, (thio)morpholiones, pyrrolidones, and their benzo-fused analogues. From combinatorial chemistry standpoint especially interesting lactams in our collection are those bearing additional functionalities, such as carboxyl, chlorosulfonyl, and amino-groups.

>> Read More : http://www.enamine.net/index.php?option=com_content&task=view&id=147

2 komentar:

  1. Pauline
    please explain about lactam building block

    BalasHapus
  2. in your blog, you write abaout Lactams can polymerize to polyamides.
    i stiil confuse,,please, explain the mecanisme of Lactams can polymerize to polyamides !

    BalasHapus